Igf-1 And The Growth Hormone - What Are They And How Do They Affect The Human Body?

 

Our bodies are a complex organism made up of several proteins, cells, organs, and tissues.

 

In order to grow properly and stay healthy everything needs to be in balance.

 

One of the main hormones that manage growth is the IGF1 HUMAN hormone.

 

This helps regulate bone and tissue growth and prevent health issues from happening.

 

Read on to learn what IGF-1 does for the human body and how you can ensure you stay healthy.

 

 

What is IGF-1?

 

IGF-1 is a hormone which manages the growth hormone (GH).

 

The two hormones together make bones and tissues grow as they normally should.

 

They are mostly produced in children, especially throughout puberty.

 

Your IGF-1 and GH levels typically decrease as you age.

 

 

How does it affect the body?

 

There are a few disorders you can develop if your IGF-1 and GH levels are imbalanced.

 

Among them are

●        Gigantism (a rare childhood disorder that causes children to grow taller than normal, have big feet and large hands.)

●        GH insensitivity or Laron syndrome (a rare genetic disorder that causes a slow growth rate and children who are shorter than normal)

●        GH deficiency (causes children to grow slower and be shorter than kids their age, or causes adults to have low bone density and less muscle mass)

●        And Acromegaly (which causes adults to have too much GH, leading to thicker bones and larger hands, feet, and facial features)

 

Most IGF-1 imbalances are found in children, not adults, since it is typically another type of disorder which causes these symptoms for them.

 

Low levels of IGF-1 in children can lead to GH deficiency or mean they have an insensitivity to GH.

 

These can be caused by a genetic disorder or a brain disease.

 

For adults, lower than normal IGF-1 levels may be due to a normal decrease due to age.

 

Higher levels lead to gigantism and acromegaly, which can most often be caused by a tumor in the pituitary gland.

 

Having high levels of both GH and IGF-1 typically leads to an acromegaly diagnosis, this may not be true if only your IGF-1 is high though.

 

Hyperthyroidism, low thyroid levels, liver disease, and diabetes mellitus that is uncontrolled may also be due to low or high IGF-1 levels.

 

Diagnosing issues

 

Some signs and symptoms that your child may have a GH disorder include

●        having a slowed growth rate (less than other kids their age)

●        Children being shorter than others your age, having smaller arms, legs, and feet

●        Men having a small penis

●        Thin hair

●         And poor nail growth that is not normal

 

For adults, the signs and symptoms may be

●        Fatigue

●        Decreased muscle mass or bone density

●        And small penis, for men

 

You can tell what your GH levels are, typically, by measuring your IGF-1 levels.

 

This can be done with a Somatomedin C test which is done by collecting a sample of the blood from the veins in your arm using a small needle.

 

Fasting, malnutrition, and age affect the results of a Somatomedin C test.

 

Other tests that may be ordered include

●        a GH stimulation test (to diagnose GH deficiency)

●        GH suppression test (to diagnose GH excess)

●        or an IGBP-3 test (checks levels of the IGBP-3 protein which carries IGF-1 to diagnose deficiency, insensitivity, or excess of GH)

●        An x-ray to measure bone age

●        thyroid function test (to rule out thyroid issues)

●        For children, medicines like Clonidine, Arginine, or Glucagon may be given to help in measuring GH levels

 

 

 

Treatment

 

Through diet and exercise you can regulate GH since it does fluctuate throughout the day.

 

IGF-1 levels, on the other hand, do not fluctuate.

 

Some children benefit from a GH supplementation treatment.

 

This includes injecting synthetic human growth hormones.

 

These injections, if given early on, can cause children to grow several inches within the first year of treatment, or grow less and slower.

 

Even if they grow less and slower in the first year, they will still benefit from the treatment, in the long run.

 

If it is found that you have a tumor causing gigantism or acromegaly, you may benefit from radiation surgery, and/or medicine.

 

In conclusion, IGF1 HUMAN and GH work together to help our bodies grow properly and decrease as we age past puberty.

 

 

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